Oral administration of a hydrophilic extract of Polypodium leucotomos for the 
prevention of polymorphic light eruption.
Tanew A. et al. / Journal of the American Academy of Dermatology, 2012, Vol. 66 No. 1
Fernblock, a Nutriceutical with Photoprotective Properties and Potential Preventive
Agent for Skin Photoaging and Phontoinduced Skin Cancers
González S. et al. / International Journal of Molecular Sciences, 2011, 12, 8466-8475 
Current Trends in Photoprotection - A New Generation of Oral Photoprotectors
González S. et al. / The Open Dermatology Journal, 2011, Vol. 5, 1-9
Oral polypodium leucotomos extract photoprotective activity in 57 patients with
idiopathic photodermatoses.
Caccialanza M., Recalcati S., Piccinno R./ Giornale Italiano di Dermatologia e Venereologia, 2011, Vol. 146 No. 2, 85-87
Mechanistic insights in the use of a Polypodium leucotomos extract as an oral
and topical photoprotective agent.
González S., Gilaberte Y., Philips N. / Photochemical and Photobiological Sciences, 2010, 9, 559–563
Polypodium leucotomos extract: A natural antioxidant and photoprotective tool
for the management of UV-induced skin damage and phototherapy.
González S. / Cosmetic Dermatology, 2009, Vol. 22, No. 12
Polypodium Leucotomos Extract Decreases UV-Induced Cox-2 Expression and
Inflammation, Enhances DNA Repairs, and Decreases Mutagenesis in Hairless Mice
Zattra E. et al. / The American Journal of Pathology, 2009, Vol. 175, No. 5, 1952-1961
Cancer cell growth and extracellular matrix remodeling mechanism of ascorbate;
beneficial modulation by P. leucotomos.
Philips N., Dulaj L., Upadhya T. / Anticancer Research, 2009, No.: 10158-P, 29(8):3233-3238
Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar
collagens and transforming growth factor-b by Polypodium leucotomos, directly
or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells.
Philips N. et al. / Archives of Dermatological Research, 2009, Aug, 301(7), 487-95
Polypodium leucotomos inhibits ultraviolet B radiation-induced immunosuppression.
Siscovick JR. et al. / Photodermatology, Photoimmunology + Photomedicine, 2008, 24, 134–141
Photoprotective activity of oral polypodium leucotomos extract in 25 patients with
idiopathic photodermatoses.
Caccialanza M. et al. / Photodermatology, Photoimmunology + Photomedicine, 2007, 23, 46–47
Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium
leucotomos extract: a randomized double-blind placebo-controlled study.
Middelkamp-Hup MA. et al. / Journal of European Academy of Dermatology and Venereology, 2007, 21, 942–950
Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization
and photodecomposition.
Capote R. et al. / Journal of Photochemistry and Photobiology, 2006, 82, 173-179
Oral Polypodium leucotomos extract decreases ultraviolet-induced damage
of human skin.
Middelkamp-Hup MA. et al. / Journal of the American Academy of Dermatology, 2004, Vol. 51 No. 6
Orally administered Polypodium leucotomos extract decreases
psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin.
Middelkamp-Hup MA. et al. / Journal of the American Academy of Dermatology, 2004, Vol. 50 No. 1
Predominant effects of Polypodium leucotomos on membrane integrity,lipid  
peroxidation, and expression of elastin and matrixmetalloproteinase-1 in
ultraviolet radiation exposed fibroblasts, and keratinocytes.
Philips N. et al. / Journal of Dermatological Science, 2003, 32, 1-9
The antioxidant action of Polypodium leucotomos extract and kojic acid: reactions
with reactive oxygen species.
Gomes AJ. et al. / Brazilian Journal of Medical and Biological Research, 2001, 34, 1487-1494
An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines
balance in vitro and appears to exhibit anti-angiogenic activities in vivo: pathogenic
relationships and therapeutic implications
González S. et al. / Anticancer Research, 2000, 20, 1567-1576
Topical or oral administration with an extract of Polypodium leucotomos prevents
acute sunburn and psoralen-induced phototoxic reactions as well as depletion
of Langerhans cells in human skin.                                                             
González S. et al. / Photodermatology, Photoimmunology + Photomedicine, 1997, 13, 50-60
Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidatio, erythema and skin photosensitization by polypodium leucotomos               
González S, Pathak MA. / Photodermatology, Photoimmunology + Photomedicine, 1996, 12, 45-56